Sheikh Shihabuddin Suhrawardi, known as Sheikh Ishraq, and Mir Muhammad Baqir Astarabadi, known as Mirdamad, are two great philosophers who believed in the principality of nature in their philosophical system and organized the other issues of their philosophical system based on it. At first glance, it seems that these two philosophers principally agree on the principality of nature and the sub-principles on which it is based, but by examining the works of these two philosophers some differences appear, differences which have had a special impact on their philosophical system and have led to completely different results. By collecting data through the library method, this article addresses the differences between Sheikh Ishraq and Mirdamad on the principality of nature. Therefore, using the descriptive-analytical method, the views of these two philosophers on the principality of nature are reviewed. The research findings show that although both philosophers believe in the principality of nature, they differ in their interpretation and the sub-principles that are based on it.