Histopathological study of wound healing of gastrotomy in rabbits with Polyglactin 910 yarns impregnated with Phenytoin and Theranekron

Gastric ulcers are created by various reasons. Faster healing of wounds is more challenging to researchers. The aim of this study was to histopathgological evaluation of the effect of phenytoin and theranekron-impregnated polyglactin 910 yarns on healing process of gastric surgical wound in the rabbits. Twenty-one male white Newzland rabbits were divided into three groups of control, phenytoin and theranekron. A gastrotomy incision with one cm in length was made in the greater curvature of the gastric wall, and then was sutured in Cushing pattern with phenytoin and theranekron-impregnated Vicryl yarn. For histopathological evaluation at days 3, 7 and 21 after surgery tissue samples were taken and stained with hematoxylin eosin and Masson-Trichrome. Histopathological changes were analyzed by using the Kruskal-Wallis test. The results of the histopathological studies showed that in the phenytoin and theranekron groups the rate of inflammatory cells, fibroblasts and vascularization were significantly (P<0.05) lower than  the control group and rate of epithelial cell formation was significantly higher than  the control group but between phenytoin and theranekron groups were not significantly difference.