The Effect of Two Types of Interval Training Intensity on Mitochondrial NRF1 and NRF2 Mitochondrial Gene Expression in Male Rats Myocardial Infarction Models

Mitochondrial biogenesis is a complex cycle that involves the coordination between the expression of mitochondrial genes and nuclear genes, and then the entry of products into the organelle and the continuity of the circulation of this cycle. The purpose of this study was to investigate the effect of two types of interval training intensity on mitochondrial NRF1 and NRF2 mitochondrial gene expression in male rats’ myocardial infarction models

In this experimental study, 24 male stroke rats exposed to isoproterenol, were randomly divided into three groups: high-intensity intermittent exercise (HIIT), moderate-intensity intermittent exercise (MIIT), and control (C). Exercise groups were influenced by periodic exercise for 8 weeks. Exercise in the two groups of high and medium intensity, with the same distance traveled, included 10-minute activities with an intensity of 85-90 and 70-65% VO2max.;at this time the control group did not have a training program. Mitochondrial NRF1 and NRF2 gene expression was obtained by real-time PCR.

Significant differences were observed in the expression of mitochondrial NRF1 and NRF2 genes in cardiomyocytes of male myocardial infarction rats in three training and control groups (p≥ 0.001). The results of Tukey test showed a significant increase in NRF1 and NRF2 gene expression in the two interval training groups compared to the control group (p≥ 0.001). However, HIIT had more effects

In general, HIIT and MIIT appear to increase myocardial mitochondrial biogenesis..