The Effect of Aqueous Extract of Crocus sativus Style on Blood Coagulation Indices in Rats

The study of pharmacological properties of saffron and its effective substances is important considering its clinical and health applications. Arterial and venous blood clot embolism is the most common cause of death worldwide, and cardiovascular disease currently accounts for almost half of all non-communicable diseases. Saffron is one of the medicinal plants used in Iranian medicine to treat heart disease. In this regard, according to reports on lipid peroxidation in platelet membranes and inhibition of platelet adhesion in the blood of healthy people by the use of saffron. In this regard, an experiment was performed to investigate the effect of saffron style extract on blood coagulation process in rats. In a 21-day period, the effect of concentrations of 15, 25 and 50 mg/kg of aqueous extract of saffron style in eight replicates on the parameters of prothrombin (PT), relative thromboplastin time (APPT) and coagulation time (CT) One-month-old male rats were studied in the laboratory of the Faculty of Basic Sciences of Ferdowsi University of Mashhad and the results were analyzed by t-test. Concentration of 50 mg/kg caused a significant increase in prothrombin time. In measuring thromboplastin time, the concentration of 25 aqueous extracts of saffron style made a significant difference at the level of 5% compared to the control. Blood coagulation time in all treatments was 7 seconds. Treatment of 15 mg/kg aqueous extract of saffron straw caused a significant reduction (at the level of 5%) in the number of blood platelets. The findings of this study show the coagulation effect of aqueous extract of saffron style and can be helpful for the optimal clinical use of saffron and also in conducting additional research in this field.