Association of Serum Anti-Heat Shock Protein 27 Antibody with Obesity Risk among Healthy Individuals in MASHAD Study

The association between the serum antibody titer of several heat shock proteins (HSPs) and cardiovascular disease (CVD) risk factors so far has been the subject of several previous studies. To evaluate the association of adiposity indices and HSP-27 antibody titers in healthy individuals. Overall 4823 individuals were recruited from Mashhad Stroke and Heart Atherosclerotic Disorders Study (MASHAD study), that included 1496 individuals with normal-weight (body mass index (BMI) <25 kg/m2), 1975 individuals with over-weight (BMI 25-30 kg/m2), and 1352 individuals with obesity (BMI≥ 30 kg/m2). The serum anti-HSP-27 antibody titers were not significantly different among obese individuals [0.21 (0.11 – 0.34) absorbency unit (AU)], over-weight individuals [0.19 (0.10 – 0.33) AU] and normal-weight individuals [0.19 (0.10 – 0.33) AU]. we have found no significant relationship among anti-HSP-27 antibody concentration and degrees of adiposity among Iranian adults.