Scrophularia striata: Therapeutic and Healing Properties with an Emphasis on Oxidative Stress and Gastric Ulcer Treatment

Some plants, including Scrophularia striata, have traditionally been used among people of the Zagros region for infection and wound healing. Therefore, the purpose of this research was to investigate the therapeutic and healing effects of S. striata with an emphasis on oxidative stress and gastric ulcer treatment. Antirrhinum majus, with a local name of S. striata, is a wildling and perennial plant from the A. majus family, found in most temperate and tropical regions of Iran, including Ilam. Substances, including cinnamic acid, quercetin, isorhamnetin-3-O-rutinoside, nepitrine, phenylpropanoid glycoside (osteoside 1), alcohol allyl, and D-N-octyl phthalate, have been identified in S. striata. People living in Ilam province have been using this plant experimentally for many years in various forms such as edible decoction, incense, and poultice in the treatment of various diseases such as inflammation and infection of the eyes and ears, skin burns, infectious wounds, episiotomy, pain, gastrointestinal disorders, colds, hemorrhoids, and boils. The S. striata extract has a significant positive effect on the size and number of gastric ulcers, and with increasing the concentration of the extract, the size and number of the wounds decrease. In general, the present study showed that the S. striata medicinal plant has a significant restorative effect on skin and gastrointestinal wounds, especially gastric ulcers, but clinical trials are required for the oral and therapeutic use of S. striata.