Primary Malignant Melanoma of Uterine Cervix with Disseminated Involvement of Lower Genitourinary Tract

 Primary malignant melanomas (MM) of the female urogenital tract are extremely rare and aggressive neoplasms. The majority of these neoplasms occur in postmenopausal women, originate from the vulva and vagina, and involvement of the uterus, cervix, and ovary is exceedingly uncommon.

 We presented a patient with MM of the uterine cervix, first diagnosed with a punch biopsy of the lesion, which was distributed from the cervical mass to the vestibule and labia minor. She underwent anterior pelvic exenteration. Pathology evaluation revealed primary MM of uterine cervix in FIGO stage III. She received adjuvant treatment with radiation and immunotherapy. On her fallow up 1 year after her disease diagnosis, she is still alive without evidence of distant metastasis.

 When feasible, pelvic exenteration offers appropriate initial management in cervical MM.