In traumatic brain injury many objects may enter the cranium, if these injuries are associated with the entry of contaminated foreign bodies into the brain; they can cause more damage and complications. This is a case report of such patients with different aspects of treatment. We reported a case followed motor accident suffered dirty large scalp lacerations, multiple linear and depressed skull fractures, and exposure to dura matter, pneumocephalus, and many sands and soil under the cranium. Several therapeutic actions were done including adequate irrigation, administration of Prophylactic antimicrobial and anticonvulsant therapy, and early surgical intervention. The Patient did not show any signs or symptoms of infections or other complications during the hospitalization period and he had a favorable 10-month follow-up period. We concluded in penetrating brain injury with contaminated foreign bodies, adequate irrigation and early administration of prophylactic antibiotic therapy and antiepileptic agents associated with early neurosurgical intervention can be helpful in complications prevention.