The effect of aerobic and interval training on adropine levels and insulin resistance in overweight men

Exercise, as a practical solution, plays an important role in increasing adropine, improving insulin resistance, and preventing the effects of being overweight. The aim of the present study was to investigate the effect of aerobic and interval training on adropine levels and insulin resistance and their relationship with insulin resistance in overweight men.

Twenty-four overweight young men with an average age of 28.4±3.14 years, 77.11±4.89 kg and body mass index27.76±.37kg/m2 voluntarily participated in the present study and were randomly assigned to aerobic exercise (n=8), intense intermittent exercise (n=8) or control (n=8). Interval exercise (with theintensity of maximum heart rate of 90–100) and aerobic exercise (with the intensity of 50–75% of maximum heart rate) for 6 weeks, 3 alternating sessions per week, for 45 to 65 minutes have been done. Before and after the interventions, blood samples were collected to measure adropine, glucose, and insulin levels in the 12-hour fasting state.

The results showed that 6 weeks of moderate-intensity aerobic exercise, as well as 6 weeks of interval exercise, led to a significant increase in adropine and a significant decrease in insulin, glucose, and insulin resistance in overweight men (P<0.05). Also, there was a significant negative relationship between changes in adropine, glucose, and insulin resistance (P<0.05). There was no significant relationship between adropine serum levels and blood insulin (P>0.05).Discussion and

It is concluded that both moderate-intensity aerobic exercise and interval exercise reduce insulin resistance in overweight men and lead to the prevention of diabetes and cardiovascular disease.  Adropine appears to play a role in these exercise-induced changes.