How Much Does Thrombocytopenia Affect the Predictive Risk of Mortality Score (Prism Ⅲ) in Critically-ill Children?

The main goal of the pediatric intensive care unit (PICU) is to reduce mortality. PRISM is one of the predictor models of mortality in patients admitted to the PICU. This study aimed to evaluate the effect of thrombocytopenia on the predicted death rate (PDR) in pediatrics admitted to the PICU, by the PRISM scoring system. This cross-sectional study was performed on patients admitted to the PICU of Akbar Hospital, Mashhad, Iran, from March 2019 to March 2020. Based on the information collected during the first 4 h of patient admission to the PICU, the PRISM score was calculated by the PRISM online calculator. The percentage of PDR calculated for each patient indicated the possibility of patient mortality. Statistical analysis was carried out using SPSS software (Version 25, SPSS Inc., Chicago, IL, USA) at the significant level of α=0.05. The results of the data analysis demonstrated that along with increasing the severity of thrombocytopenia, an increase in the average PDR was observed. Furthermore, the findings revealed a significant correlation between the average PDR and the death of patients. It can be concluded that the effect of thrombocytopenia on mortality is greater than that considered in the PRISM scoring system.