Effects of Flaxseed Oil and Olive Oil on Markers of Inflammation and Wound Healing in Burn Patients: A Randomized Clinical Trial

To study the anti-inflammatory and antioxidant effects of flaxseed oil and olive oil on inflammatorymarkers for facilitating wound healing. One hundred and twelve patients were randomly selected to four groups with a total burn surfacearea (TBSA) of 20-50%. The four groups includes olive oil (OO), flaxseed oil (FO), mixture of olive oil andflaxseed oil (OF), and control group and received 30g of oils for three weeks. Serum high-sensitivity C-reactiveprotein (hs-CRP), ferritin and albumin level as inflammatory markers, as well as cholesterol, triglyceride,high-density lipoprotein (HDL) and low-density lipoprotein (LDL) as the lipid profile were explored. Woundhealing was assessed by photographing on days 2, 8, 15, and 22 (during three weeks of intervention) and wereanalyzed in imageJ software. The greatest reduction in the level of hs-CRP and ferritin was observed in the OF (-21.38±44.41)(-132.79±165.36), while the lowest reduction was reported in the control group (-36.36±79.03) (141.08±262.36).Compared to control group, OO significantly increased albumin (0.88±0.65). Reduction of wound healing at theend of the first week of intervention was not significant in the study groups. However, the stereology examinationshowed significant improvement in wound healing at the end of the second and third weeks in the OF. Based on the findings, combination of herbal oils reduce inflammation and improve wound healingand showed positive effects on the size of wounds in burn patients.