Hydrogel Based on Alginate-Polyethylene Glycol Polymer Containing Scrophularia striata Extract Nano-Liposomes is an Excellent Nano-Phyto-Extract in Wound Healing; a Geometric and Pathological Study

Due to the anti-inflammatory and antioxidant properties of Scrophularia striata, it is used to heal wounds. Today, hydrogel based on alginate-polyethylene glycol polymer is mainly used due to its drug delivery properties and create of suitable conditions for wound healing. In this study, we tried to investigate the effect of hydrogel based on alginate-polyethylene glycol polymer containing Scrophularia striata extract nanoliposomes on wound healing in rat animal models. Field emission scanning electron microscopy and dynamic light scattering were used to examine nanoliposome and hydrogel. 126 Wistar albino rats were randomly divided into 7 groups (18 rats/group). The rats were anesthetized and their dorsum shaved, a burn wound was created with a cylindrical copper at 100° C. Rats' wounds were treated with hydrogel Scrophularia striata extract and on the 5th, 10th, and 15th days, histopathological evaluation, macroscopic features and wound healing were evaluated and analyzed in different groups. The structure of nanoliposomes was uniform and the size was 80-110 nm. Also, the size of the hydrogel was 320 nm with nanometric size and spherical morphology. Histopathological evaluation, wound area and wound contraction confirmed that the treatment group had a significant difference from other groups and the effect was almost similar to that of zinc oxide. This study showed that alginate-polyethylene glycol polymer containing Scrophularia striata extract caused wound contraction, and reduced wound area, and can be used for wound healing.