The effect of exercise training on the circulating levels of BDNF in patients with multiple sclerosis: a systematic review with meta-analysis

Author(s):

Mousa Khalafi* , Mohammad Borzuk , Amir Ghanbarpour

Message:
Article Type:
Review Article (دارای رتبه معتبر)
Abstract:
Background

Brain-derived neurogenic factor (BDNF) plays an effective role in improving neurological processes, therefore it is a therapeutic target for patients with multiple sclerosis (MS). This meta-analysis aimed to investigate the effect of exercise training on the circulating levels of BDNF in patients with MS.

Materials and Methods

PubMed, Scopus and Web of Science databases were searched until April 2023 for exercise training studies on BDNF circulation levels in MS patients. This search was performed using the keywords: "exercise training", "BDNF" and "MS". Standardized mean difference (SMD) effect sizes and 95% confidence intervals were calculated using CMA2 software.

Results

20 exercise interventions from a total of 15 studies including 603 subjects with MS were included in the meta-analysis. The results of data analysis showed that exercise training with a small and significant effect size leads to an increase in the circulating levels of BDNF in patients with MS [0.45 (CI: 0.18 to 0.72), P=0.001].

Conclusions

exercise training leads to the positive regulation of BDNF in patients with MS, which may play an important role in controlling this disease.

Keywords:

Exercise training , BDNF , Multiple sclerosis

Language:
Persian
Published:
Feyz, Volume:27 Issue: 2, 2023
Pages:
967 to 977
https://www.magiran.com/p2587175  
سامانه نویسندگان
  • Khalafi، Mousa
    Corresponding Author (1)
    Khalafi, Mousa
    Assistant Professor Department of Physical Education and Sport Sciences, University of Kashan, کاشان, Iran
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