The Effect of Aerobic Training before Alzheimer’s Induction on the Expressionof Calcineurin and Ca2+/Calmodulin-dependent Protein Kinase II Genein the Hippocampus of Rats with Alzheimer’s Disease

Regular aerobic exercise improves learning, memory, and cognitive and SynapticPlasticity in Alzheimer’s disease (AD) patients. The aim of this study was to evaluate the levels ofcalcineurin and Ca2+/calmodulin-dependent protein kinase II mRNA after four weeks of aerobic trainingexercises and before AD induction in the hippocampus of male Wistar rats.

Thirty 8-week-old rats with an average weight of 195±20 g were initially randomlydivided into two groups of aerobic exercise or rest for four weeks. Then, each group was divided intothree groups of AD, sham, and injection. Then, 48 hours after the last training session, Aβ1-42, or DMSOwas injected into the hippocampus. Finally, after the isolation of the hippocampus, CaN mRNA and CaMKIImRNA levels were measured.

The results of this study showed that there was a significant difference between the groups inmRNA CaN and CaMKII mRNA levels (P<0.05). The results showed that aerobic exercise and AD pre-inductionhad a significant effect on increasing calcineurin and Ca2+/calmodulin-dependent protein kinaseII levels.

Overall, the findings of the present study showed that four weeks of aerobic training improvesthe molecular signaling of neuroplasticity in AD rats.