The Effect of Moderate-intensity Continuous Exercise and NanocurcumineSupplementation on STAT3 Gene Expression in Rats With GlioblastomaMultiforme Brain Tumor

Continuous exercise with moderate intensity and the use of nanocurcuminsupplementation has the potential to control and reduce tumors of the central nervous system, includingglioblastoma. We assessed the simultaneous effect of moderate-intensity continuous exercises andnanocurcumin supplementation on STAT3 gene expression in mice with glioblastoma multiforme braintumors.

Subjects and Methods:

 Thirty-five male Wistar rats were randomly divided into seven groups of fiverats: basal control (BC), 4-week control (4wC), basal cancer control (BT), 4-week cancer control (4 wT),cancer+training (TE), cancer+nanocurcumin (TN), cancer+ exercise + nanocurcumin (TEN). After injectionof cancer cells in the forehead, the animals were treated with nanocurcumin by gavage at the dose of 80mg/kg for 28 days, five days a week, and started moderate-intensity continuous training on the treadmillfor four weeks, three days/weeks, 25 to 40 minutes per week at a speed of 18 m/min. Finally, and thenrats were sacrificed and data were collected.

Moderate-intensity continuous training with nanocurcumin supplementation significantly reducedtumor volume and STAT3 gene expression in the TEN group (P<0.05). But this decrease was notsignificant in the TE and TN groups.

Conclusion:

 It seems that with decreased STAT3 gene expression and brain tumor size, the combinationof moderate-intensity continuous training and nanocurcumin supplementation has a therapeutic role inthe treatment process of glioblastoma multiforme brain tumors.