Investigating the antifungal effects of Carvacrol and 1,8-cineole on Candida albicans, Aspergillus flavus, Trichophyton rubrum and Epidermophyton flucosum

There are many fungal agents that can infect and clean the skin. The aim of this study was to observe the antifungal effect of Carvacrol and 1.8 cineole on fungi. In this descriptive-cross-sectional study, Carvacrol and 1.8 cineol essential oils were supplied by the microbial collection of the Scientific and inisitue Research Organization of Iran. The fungal strains Candida albicans, Aspergillus flavus, Trichophyton rubrum, and Epidermophyton flucosome were used in this study. Agar diffusion and macrodilution broth were used. Statistical tests were used to investigate the antimicrobial effect of Carvacrol essential oil and 1.8 cineole. Combination effect of carvacrol and 1,8 cineol against fungal species by disc diffusion method showed that these compounds had the greatest effect on Candida and carvacrol was a more effective than 1,8 cineol. A synergistic study of carvacrol with fluconazole, ketoconazole, and terbinafine showed stronger effects against fungal species. The amount of MIC and MFC obtained from carvacrol against Candida albicans, Aspergillus flavus, Trichophyton rubrum and Epidermophyton flucosome was 250, 125 – 62/5 - 125 and 62/5 and 125,62/5 ppm and this amount for 1,8 cineole, respectively, is 15, 7/8 - 15, and 7/8 -31, 7/8 - 31 and 7/8 ppm. In order to the side effects and high toxicity of common antifungals, it is recommended to use herbal compounds in combination with these antifungals and by conducting clinical studies, toxic effects, pharmacological and its side effects should also be considered.