The Effect of Eight Weeks of Aerobic Exercise with L-Arginine Supplementation on MMP-9, TIMP-2 Overweight Women

The current study was to examine the effect of eight weeks aerobic training with L argenine supplement consumption on MMP-9, TIMP-2 in overweight women. In semi experimental study with pre-post phases, 60 overweight women with age range 20-30 years old selected and those located in 4 groups: aerobic training, L argenine supplement consumption, aerobic training with L argenine supplement consumption and placebo. Blood sampling collected in pretest phase (48 hours before physical activity and supplement consumption) and post test phase (48 hours after physical activity and supplement consumption). The training protocol consisted of 8 weeks of aerobic training, which was held three sessions per week. Participants in two groups of daily 1g of L argentine supplement. Participants in the placebo group also received a placebo from dextrin. Data were analyzed by analysis of variance with repeated measures. The results showed that aerobic training, L argenine supplement consumption and aerobic training along with L argenine supplement consumption significantly increase MMP-9 and significantly reduce TIMP-2 in overweight women. Other results showed a greater effect size of aerobic training with L argenine supplement consumption compared to aerobic training and L argenine supplement consumption alone in increase MMP-9 and reduce TIMP-2. In general, along with aerobic exercise, taking L-arginine supplements (probably) can further stimulate the angiogenesis process in overweight women.