Investigation of the Changes in Sirtuin 1 Following a Course of High-Intensity Interval Running Exercise with Vitamin D Intake in Young Women with Vitamin D Deficiency

Vitamin D deficiency is a metabolic change that is often associated with obesity and sirtuin 1 (SIRT1) seems a therapeutic target for the treatment of obesity and its linked disorders. The present study investigated effects of eight weeks of high-intensity interval running exercise (HIIT) with vitamin D intake on the serum SIRT1 and 25-hydroxyvitamin D [25(OH)VD] levels in inactive women with vitamin D deficiency.

In this clinical trial study, 39 overweight women with vitamin D deficiency were selected and then randomly assigned to three groups of exercise, exercise and vitamin D (combined) and control groups. The HIIT carried out three days a week with 12 × 1-min running bouts at 80–90% HRmax interspersed and 1-min active recovery at 50% HRmax. Vitamin D was administrated weekly at a dose of 50,000 U. Data were analyzed using one-way ANOVA with repeated measures and one-way ANOVA (Kruskal-Wallis for non-normal data) at a significance level of less than
p < 0.05.

After eight weeks, increases of serum 25(OH)VD and SIRT1 in the intervention groups were significant; however, the body weight decreased significantly (p < 0.001). Changes in these variables were higher in the combined group than the HIIT intervention alone group (p < 0.001).

It seems that lifestyle changes including HIIT and vitamin D intake are important approaches that can decreased obesity-linked complications by increasing SIRT1 and 25(OH)VD and the simultaneity of these interventions helps develop these effects.