The Effect of 8 Weeks of Aerobic Exercise Along with Nano-Curcumin on the Expression of Atrogin-1 and Murf-1 Genes in Soleus Muscle of Male Wistar Rat:A Short Report

The present study aimed to investigate the effects of eight weeks of taking nano-curcumin and performing aerobic exercise on the expression of Atrogin-1 and Murf-1 genes in the soleus muscle of male Wistar rats.

This experimental study was conducted on 32 rats. Aerobic exercises were performed 5 times per week, and nano-curcumin was administered to rats at 80 mg per kg. The real-time PCR (Polymerase chain reaction) technique was employed to measure gene expression, and two-way analysis of variance (ANOVA) was used to analyze the data. 

The results showed that aerobic exercise significantly decreased the expression levels of the MuRF-1 and Atrogin-1 genes (p<0.05). In addition, nano-curcumin supplementation without aerobic exercise also reduced the expression levels of the mentioned genes (p<0.05).

The results of this study indicated that nano-curcumin supplementation alone decreased the expression levels of the two mentioned genes and so did aerobic exercise alone. However, their interaction effects were not significant on the expression level of the Atrogin-1 gene.