Synthesis, Spectral and Biological Studies of DHA Schiff Bases

A new series of Schiff bases derived from DHA (Dehydroacetic acid) and aromatic primary amines were synthesized and characterized by elemental and spectral (Electronic, IR and 1HNMR) analysis. The signals of 1HNMR spectrum and characteristic peaks in IR spectra are used for the molecular structure elucidation of synthesized Schiff bases. The antimicrobial activities of synthesized compounds have been screened in vitro against Escherichia coli, Staphylococcus aureus, Bacillus subtilis bacterial species, Candida albicans and Aspergillus niger fungal organism and found to exhibit strong antifungal activity than antibacterial activity. Among the studied DHA Schiff base of 2-amino-4,6-dimethylpyrimidine depicted discerning antifungal and antibacterial activities.