Association of polymorphism rs1859962 with prostate cancer in Iranian men

One of the most common malignancies in men is prostate cancer. According to genome-wide association studies (GWAS), some single nucleotide polymorphisms (SNPs) are likely factors for prostate cancer.

The aim of this study was to investigate the association between the rs1859962 polymorphism and prostate cancer risk.

This case-control study was conducted on 172 peripheral blood samples, including 72 cases of prostate cancer and 100 control subjects with BPH. The Tetra - ARMs PCR technique was used for SNP genotyping.

The results showed that the GG genotype of the rs185996 polymorphism had a significant association with prostate cancer risk in the recessive model (P=0.022; OR=3.426; 95% CI=1.135-10.344). According to the results of the dominant and additive models, there is no risk of prostate cancer in these genetic models. The polymorphism Rs1859962 was correlated with GS≥8 (P=0.021; OR=2.088; 95%CI=1.11-3.928), EPE (P=0.002) and PSA>10 (P=0.016; OR=2.133; 95%CI=1.44-3.978).

Our results suggest that the rs1859962 polymorphism is associated with prostate cancer risk in a recessive model and can be considered as a potential biomarker for screening prostate cancer patients.