Some Para clinic Factors Associated with Mortality in COVID-19: A systematic review and meta-analysis

Identifying the factors that affect the mortality of COVID-19 patients can play an important role in preventing death in these cases. Para clinical factors can be one of the effective factors on COVID 19 patientschr('39') mortality. Due to the presence of controversy between studies, this study aimed to determine the role of Para clinical factors on the mortality of COVID-19 patients in a systematic review and meta-analysis.

The current systematic review and meta-analysis were performed using PRISMA protocol in international databases including Medline / PubMed, Scopus, Google scholar. Due to the presence of heterogeneity between studies, the random effect model (95% CI)-was used to calculate the pooled odds ratio (OR) and the risk ratio (HR). Data were analyzed using Stata11 software. The Heterogeneity was assessed using Cochranchr('39')s Q indicators, I2 index, and T2 test.

the serum Creatinine, OR:1.95 (1.54-2.47), serum Bilirubin OR: 3.07(1.10-8.57), and urea Nitrogen, OR: 3.52 (1.11-10.09) increase significantly the risk of death from COVID 19(P<0.05), However, Lymphocyte count and serum Albumin didn’t show a significant relationship with the mortality of COVID-19 patients(P>0.05).

it seems some Para clinical factors, such as serum creatinine, serum bilirubin, and high levels of urea nitrogen, are associated with COVID-19 mortality. Therefore, paying attention to these factors can play an important role in reducing the mortality of these patients.