Comparison of serum and salivary folate levels in patients with oral squamous cell carcinoma

Article Type:
Research/Original Article (دارای رتبه معتبر)
Oral cancer is the sixth most common cancer in males and the fifteenth in females. Folate is essential for maintaining normal function of nucleotide synthesis and DNA methylation. Disruption of folate metabolism can lead to abnormal cell activity and proliferation. The aim of this study was to compare the serum and salivary levels of folate in patients with oral squamous cell carcinoma (SCC) and healthy subjects.
In this cross-sectioned study, 30 patients with oral SCC referred to ENT department and 30 healthy individuals were studied. Two cc saliva and 5cc venous blood were taken from participants and were evaluated with Human Folate ELISIA Kit. Independent T test and Pearson correlation coefficient was used and statistical analysis was done using SPSS 17. The result was considered to be significant if the P-value was less than 0.05.
Serum folate levels in patients with oral squamous cell carcinoma (8.18 ± 4.37 ng/mL) were significantly lower than healthy subjects (10.61±5.79 ng/mL) (P=0.005). It was also found that folate levels in saliva were significantly lower in patients with squamous cell carcinoma (1.13 ± 1.32 ng/mL) than healthy subjects (2.84 ± 4.40 ng mL) (p= 0.029).
Since the levels of serum and salivary folate in patients with oral squamous cell carcinoma were significantly lower than that of healthy individuals, low folate levels are likely to be associated with oral SCC.
Journal of Oral Health and Oral Epidemiology, Volume:12 Issue: 3, Summer 2023
130 to 133  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 1,390,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
In order to view content subscription is required

Personal subscription
Subscribe for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!