Synthesis of Metal Oxide Nano Particles by Sol-Gel Method and Investigation of its Biomedical Applications

In this investigation, CuO NPs, Cu-MnNCs, and Cu-Co NCs were synthesized by the sol gel method in the presence of the stabilizing agent polyvinyl alcohol (PVA). These nanoparticles were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and X-ray diffraction (XRD) techniques. The chemical structure and existence of bonding of PVA integration with nanoparticles were verified by the FTIR analysis. The SEM investigations revealed that the average particle sizes of CuO NPs, Cu-Mn NCs, and Cu-Co NCs were 64.5, 87.5, and 69.0 nm, respectively. Additionally, the XRD analysis supported their nano sizing. The antioxidant and enzyme inhibition activities were assessed against 2, 2-diphenyl-1-picryl-hydrazyl (DPPH) with IC50 values of 78.9, 67.8, and 60.8 g/ml, respectively. The antioxidant activities showed that they inhibited the effects of oxidative metabolites. The IC50 value is a quantitative measure that reveals the presence of certain inhibitory chemicals required to block the biological process in vitro .The biological component could be an enzyme, microorganism, or cell receptor. The enzyme inhibition activities of CuO NPs, Cu-Mn NCs, and Cu-Co NCs against urease were found to be 18.5, 23.7, and 34.5 uM, respectively. These characteristic properties suggested that these nanocomposites have biomedical applications. Moreover, they can be efficiently employed for therapeutic purposes.