In vitro investigation of the GdF3:Bi nanoparticles synthesized via hydrothermal method as the dual MRI-CT contrast agent

In the present study, the Bismuth doped GdF3 nanoparticles were synthesized via the hydrothermal method and the effect of temperature, time and NH4F concentration was investigated. The Poly Ethylene Glycol was used as the surfactant. The phases characterization was inducted via XRD, FE-SEM and EDS techniques. The in vitro investigation of the samples as the contast agents were performed using MR and CT imaging. the sample synthesized at 180 oC,, 6 hours and the NH4F concentration twice the Stoichiometric concentration that had the semi spherical structure with mean size lower than 100 nm was the suitable sample and the in vitro studies show that the particles act as an excellent CT contrast agent and also as an effective MRI contrast agent at concentrations between 22.5 and 180 mM. Briefly, The use of Bismuth dopant ant GdF3 nanoparticles was successfully performed and The particles can used as the potential MRI-CT contrast agents.