The effect of curcumin and nanocurcumin in improving periodontal lesions in patients with diabetes: (A systematic review)

Inflammatory gum disease is a complication of diabetes that can impact blood sugar control. Current treatments for diabetic patients, such as scaling and gum surgery, are invasive. The present study aimed to review the effectiveness of curcumin in improving periodontal lesions in diabetic patients.

Four databases of Scopus, PubMed, Web of Science, and Google Scholar were searched for relevant studies without any time or language limitations. MeSH keywords and text words related to "curcumin," "periodontal lesions," and "diabetes" were used to search in the title-abstract field. The titles, abstracts, and full text of the studies were reviewed to identify eligible studies. The present study followed PRISMA guidelines for implementation and reporting.

Finally, 10 studies were included in the review. The results showed that curcumin can reduce free radicals and inflammatory factors, improving inflammation. Gums in diabetic patients should be scaled alone or with invasive methods.

It seems curcumin may effectively reduce gum inflammation and bone loss in diabetic patients. However, to reach a reliable conclusion, further human studies are required in this field.