Evaluation of the Side Effects of Exogenous Surfactant on Neonates Admitted to NICU ward of Ali Asghar Hospital, 2001-2003

Hyalane membrane disease(HMD) is considered as one of the common causes of mortality among premature neonates and exogenous surfactant is used as a vital treatment. The aim of the present study was to evaluate the frequency of different complications that followed prescription of exogenous surfactant in neonates of Ali Asghar Hospital from 2001 - 2003. Patients & In a cross-sectional study, all neonates with HMD who had been admitted to the NICU of Hazrat Ali Asghar Hospital and treated with exogenous surfactant underwent evaluation. 39 cases included 47.2% male and 52.8% female. The mean of age and weight was 32.12±2.89 weeks and 1725±601.8grs respectively. Lung hemorrhage which was seen in 14% of the cases including 2 males and 3 females led to their death. Decrease in blood oxygen content was noticed in 10 cases(27.7%), 6 boys and 4 girls. Hypotension occurred in 13 cases(36%), 9 boys and 4 girls. Total frequency rate of complications was significantly related to decrease in gestational age and birth weight. Mortality was statistically higher in pulmonary hemorrhage. Based on the results of this study and comparing them with the findings of other studies, we can conclude that the rate of pulmonary hemorrhage and the resulting death after exogenous surfactant therapy in this study is higher than others, which needs to be investigated by future studies. However, surveys of this kind have hardly been carried out in our country and this makes our study quite exclusive.