Immunogenecity of hepatitis B vaccine in Mazandaran medical sciences students-2004

Background and Vaccination is the most effeetive method of prophylaxy in high risk group of hepatitis B. Some individuals faile to respond to triple doses of vaccine which is potentially dangerous. Therefore, immunogenecity of triple doses recombinant hepatitis B vaccine was evaluated in a high risk group (medical sciences students). 193 healthy medical sciences students immunized with triple doses of recombinant hepatitis B vaccine (0,1,6 months). 1-2 months after the last dose, serum anti HBS antibody was determined by ELISA method. According to the antibody titer of the vaccinees (IU/L) they were classified into none responder, low, intermediate and high responder. The none responders were recommended for re-vaccination. Three students (1.6%) were detected as non responder. (<10 Iu/L anti HBS antibody), 23 (11/4%) as low responder, 141 (73%) as intermediate responder and 26 (13.5%) as high responder. The prevolence of non responders to triple doses of recombinant hepatitis B vaccine in medical sciences students was very low.