The Effect of Intravascular Replacement Solution Type on Coagulation in Adult Patients Undergoing ACL Reconstruction Surgery with General Anesthesia

Crystalloids represent an attractive strategy to alleviate intravascular volume deficits. Studies have demonstrated that hemodilution with decrease antitrombin III is associated with hypercoagulability. However, there were not any researches about effect of different crystalloids on coagulation. The present study was undertaken to find out which of the used crystalloids has more effect on coagulation. Patients & In a prospective study on patients undergoing ACL reconstruction normal saline(NS), Ringer(R) and Ringer Lactate(RL)(n=25) were used for intravascular volume replacement based on standard protocol to compensate intravascular volume deficits. PT, PTT, BT, CT and platelet count were used at T0(after induction of anesthesia), T1(immediately after anesthesia), T2(6h after surgery) and T3(the morning after surgey), for comparing coagulability in groups. Changes of coagulation at T1 in all groups were not significant. Mean(±SD) of coagulation tests at different times in all groups were statistically significant in PT(P=0.001), PTT(P=0.001), and CT(P=0.001) and not significant in BT & PLT(P>0.05). No differences between NS, R & RL were seen in coagulation tests and coagulability. However, hypercoagulability states were seen after hemodilution.