The hepatoprotective effects of Dorema auchri on carbon tetrachloride induced liver damage in rats

The liver diseases are of the most important human kind problems. The discovery of effective medicines on the diseases is the interest of specialists. A wild species of umbelliferus plants, Dorema auchri, is used as vegetable in spring season in southern regions of Iran and is thought that it has medicinal characteristics. In this study, we evaluated the hepatoprotective effects of the crude extract of D. auchri in rats treated with carbon tetrachloride (CCl4).

In an experimental study, thirty rats were divided into five equal groups. The first group served as a control and the other groups treated with CCl4 to create hepatotoxicity. Three groups of hepatotoxic rats (treaded with CCl4) were fed with 200, 400 and 500 mg/day of crude extract of D. auchri. After 45 days, the level of liver damage was measured using aspartate

aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and concentration of total protein, albumin and bilirubin in serum. The data were analyzed using statistical ANOVA test. Intraperitoneal injection of CCl4 increased AST, ALT and ALP activity to 117.85, 468.6, and 134.97 and decreased the concentration of total protein, albumin and bilirubin of serum to 16.8, 20.3, and 880 percent, respectively compared to that of the control group (p<0.001). Consumption of crude extract of D. auchri caused these factors return to the normal level.

Aqueous extract of D. auchri showed hepatoprotective activities against carbon tetrachloride induced liver damage in rats.