Lipid disorders in the first degree relatives with premature myocardial infarction in Bushehr port

Family history of premature myocardial infarction (PMI) is an important risk factor thus diagnosis and therapeutic intervention of cardiovascular risk factors in the first degree relatives of the patients with PMI is the most effective measure for preventing myocardial infarction and its mortality rate. Cardiovascular risk factors were assessed in the relatives of 49 patients with PMI in Fatemeh-Zahra University Hospital using MONICA-WHO project and Behavioral Risk Factor Surveillance System (BRFSS) criteria. A control group with the age of over 25 years old was randomly selected among the subjects of the Persian Gulf Healthy Heart Study (PGHHS). Lipid and lipoprotein abnormalities were defined according to National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III). A total of 148 (88 females and 60 males) first degree relatives of 49 patients with PMI were evaluated. The frequency of hypercholesterolemia, high LDL-cholesterol, low HDL-cholesterol and hypertriglyceridemia in subjects with less than 20 years old (42 first degree relatives) were 33.3%, 28.5%, 71% and 16.6%. No significant difference in frequency of hyperlipidemia and the other cardiovascular risk factors was found between the first degree relatives of patients with PMI and their age – and sex – matched control subjects (P>0.05). We also found no significant difference in frequency of lipid abnormalities between the patients with PMI and their age – and sex – matched control subjects however these patients had a higher frequency of diabetes mellitus (28.1% versus 6.5%) and hypertension (56.3% versus 22.6%), in comparison to the control group. Lipid and lipoprotein abnormalities in the first degree relatives (≥25 years old) of patients with PMI are the same as normal general population therefore investigation of novel cardiovascular risk factors should be considered for further evaluation.