Surveying the Side Effects of Non-Steroidal Anti Inflammatory Drugs among Patients with Helicobacter Pylori Infection and Non-Infected Subjects

Controversies exist regarding the role of helicobacter pylori infection in NSAIDs-induced GI bleeding. Thus, the present study was conducted to compare the frequency, risk factors and signs and symptoms of NSAIDs-induced GI bleeding among infected and non-infected subjects with H. pylori.

In a cross sectional study, all 256 cases of GI bleeding following NSAIDs usage were enrolled. They undertook endoscopy. H. pylori infection was evaluated by urease test.

The study population included 94 males and 162 female with the mean (±SD) age of 55.3±10.9 years. Among these, 190 had positive urease test and the remaining 66 were negative (p<0.05). Female gender, smoking, and alcohol consumption were significantly more common among H pylori-infected individuals.

Our study revealed that H pylori infection is common in patients who develop NSAIDs-induced gastro-intestinal bleeding and may increase the risk of bleeding following NSAIDs usage.