THE STUDY OF QUERCETIN EFFECTS ON BEHAVIORAL AND NIGROSTRIATAL TISSUE IN THE EXPERIMENTAL MODEL OF PARKINSON IN ADULT RAT

The aim of this study is investigating the effect of quercetin on behavioral and nigrostriatal tissue in the experimental model of Parkinson in adult rat In this study we used 80 male rats from Wistar spring with body weight of 200-250 g. In order to make parkinson model 6-OHDA (12.5 mg/kg) was injected intrastriatal unilaterally using stereotaxic method. Lesion rats were pretreated intraperitoneally with quercetin (20 mg/kg) one hour before surgery and once a day with 10 & 20 mg/kg doses up to one month after surgery. Rotational behaviore of apomorphine-induced postlesion was measured during the fifth week after surgery considered as treatment efficiency indicator. SNC cells were studied with nissle staning method. Behavioral tests in the fifth week revealed that Apomorphine caused evident contralateral rotation in lesion group (P