Serum Lipid Peroxides Level as a Risk Factor in Male Patients with Coronary Artery Diseases

Lipid peroxidation has recently attracted considerable attention. It has been linked to carcinogenesis, aging and variety of other diseases including atherosclerosis. Atherogenesis involves the complicated interaction between cells of the arterial wall and lipoproteins (mainly oxidized LDL). The aim of this study was to investigate the relationship between serum malodialdehyde (MDA), the important indicator of lipid peroxidation and alteration in serum lipids and lipoproteins concentrations in male patients with coronary artery disease (CAD). The subjects of this study were 51 male patients under 55 with angiographically comfirmed CAD admitted to Shahid Madani Hospital and 60 age and sex matched apparently healthy individuals as the control group. The serum level of MDA was measured by colorimetric method using thiobarbituric acid reaction and lipid and lipoproteins concentrations were determined by standard enzymatic methods. Significant elevation in the level of MDA was noticed compared to the controls (P=0.03). Serum concentrations of cholesterol, triglyceride, LDL-C and LDL - C /HDL - C ratio in cases were higher than those of the controls (P=0.03). There was a positive and significant relationship between serum MDA and biochemical risk factors including Triglyceride, Cholesterol, LDL-C and LDL - C/HDL - C ratio (p=0.03). The correlation between serum MDA and serum HDL-C was negative and meaningful (P=0.03). No relationship was observed between serum MDA with BMI and age in cases. Simultaneous control and monitoring of both dyslipoproteinemia and lipid peroxidation may be of equal importance in prevention of occurrence and progression of CAD.