The relationship between diameter and number of follicles and endometrial thickness and pregnancy success after intrauterine insemination (IUI)

Induction ovulation and intrauterine insemination is one of the therapeutic approaches for male infertility. Timing of intrauterine insemination based on number and diameter of follicles and endometrial thickness is essential to maximize pregnancy rate and minimize complications such as hyperstimulation syndrome. Therefore this study was done for evaluation of relationship between pregnancy rate and number and diameter of follicles and endometrial thickness after induction ovulation with clomiphene citrate and IUI. Methods and Materials: In this case-control study in 2001among patients referring to Mashhad infertility center, 100 Patient were randomly assigned to case (50 pregnant women) or control (50 non pregnant women) group. The number and diameter of follicles and endometrial thickness were evaluated and compared by transvaginal ultrasound in these 2 groups in the day of injection of Human Chorionic Gonadotropine. Results of study were analyzed by chi – square, T-test, ANCOVA and multiple regressions. This study was revealed that there is significant differences between pregnancy rate and follicles diameter in two groups (P=0.38, X2=5.8). Also in two groups there is significant differences between pregnancy rate and follicles number (P=0.01, R=0.29). There is significant differences between pregnancy rate and endometrial thickness in two groups (P=0.033, R=0.29). In this study “pregnancy rate was correlated with number and diameter of follicles and endometrial thickness after induction of ovulation with clomiphene citrate and IUI”.