THE EFFECTOFINTRAPERITONEALINJECTION OF HISTIDINE ON DEFECATION RATE IN RABBITS

Histidine at the doses 30 and 60ml /kg had no effect when injected at 7: OOh, or at 19:00h. Histidine at the doses of 120, 240 and 480 mg / kg decreased defecation at the first 8 and 24 hours post injection, respectively, when injected at 07:00h. The amino acid at the doses of 120, 240 and 480 mg / kg decreased the number of fecal pellets at 2, 8 and 24 h post injection, respectively, when injected at 19:00h. Suppressive effect of histidine in the light period was more intense and lasted longer than that in the dark period. The mean number of pellets for each individual prior to the interventional study was recorded as interval negative control.