Waldenstrom ́sMacroglobulinemia in Cryptogenic Cirrhosis

The coexistence of Waldenstrom´s macrglobulinemia and cryptogenic cirrhosis has been rarely reported.We describe a 72-year-old man with compensated cryptogenic cirrhosis whose major clinical presentation was hyperviscosity syndrome. Serum protein electrophoresis revealed the presence of an IgM-kappa spike. Lambda light chain was found in urine. Bone marrow biopsy was performed, which showed at least 22%infiltration with atypical plasma cells. No bone lesion was found. ByWaldenstrom´smacroglobulinemia diagnosis, patient treated with melphalan, thalidomide and dexamethasone. After three weeks of treatment, his symptoms disappeared and serum immunoglobuline M decreased below 1000 mg/dl.