Effect of Isolated Soy Protein on Prevention of Rheumatoid Arthritis in Collagen- Induced Rats

Background and Objectives The aim of this study was to investigate the effect of isolated soy protein on prevention of rheumatoid arthritis in collagen-induced rats. Methods A total of 24 female Sprague-Dawley rats (body weights: 180-200g) were randomly divided into four equal groups including normal; control of rheumatoid arthritis; rheumatoid arthritis + isolated soy protein (7g/kg); rheumatoid arthritis + dexamethasone (1mg/kg). Experimentally rheumatoid arthritis in rats was induced by subcutaneous injection of collagen ΙΙ emolsified in Incomplete Frund s Adjuvant in days 1 and 7. Treatments were gavaged to animals for 30 days once a day. The severity of rheumatoid arthritis symptoms in paws were daily measured in double blind format by standard method. The statistical comparison between the experimental groups was performed by Independent -samples t- test and One-Way ANOVA using SPSS software. Results The clinical symptoms of rheumatoid arthritis started from day 17.4±2.4 20±4 and 14.1±1.9 in isolated soy protein dexamethasone and control groups respectively (P