COMPARISON OF CONSTANT DOSE WITH VARRIABLE DOSE OF PROPOFOL FOR STUDYING TIME OF WAKE UP WITHIN BISPECTRAL INDEX, (BIS) MONITORING

Propofol is a IV anesthetic which produces hypnosis and bispectral index (BIS), a parameter derived from the electroencephalograph (EEG), target of this study is comparing wake up time after termiation of surgery at control group which received constant dose of propofol with study group which received variable dose of propofol within BIS monitoring. This study performed on fifty patient which candidated for vertebral column surgury according to a randomed clinical trial study those receiving a propofol sufentanil anesthetic were studied in a general hospital center. Patient randomly divided to townty five persons in every group. BIS was recorded for all patients. In the BIS group, propofol were adjusted to achieve a target BIS between 40-50 in another group propofol was constant (150μg/kg). Drug use intraoperative responses and patient recovery parameter were recorded. Monitoring consist of BIS index, vital sign (HR, BP) and time of wake up was measured. Compared with the first group (BIS group), patients in the second group required propofol infusion rate (150μg/kg/min), were waked up sooner 549 vs 480 second, p<0.05, had a higher percentage of patients oriented on arrival to PACU (45%vs 19% p<0.05). total dose of propofol which consumed within surgery that last about 120±30 minutes for all patients for first group was about 980mg and for second group was 1240mg. Titrating propofol with BIS monitoring during TIVA anesthesia decreased propofol use and significantly improved recovery. Intraoperative course was not changed. These findings indicate that the use of BIS maybe valuable in guiding the administration of propofol.