Short Communication: SeroPrevalence of CMV in women's with spontaneous abortion in kowsar hospital, Ilam during 2007-2008

Human CMV is the most causative agent of a very common viral infection contacted by most adults that have no noticeable or with only mild uncharacteristic symptoms. However when a pregnant women is infected with CMV as a primary infection, there is a risk for transmission of virus to the fetus as well as reactivation of virus in rare case. HCMV antibodies were already described in spontaneous abortion and fetal abnormalities cases. Also antibodies against HCMV in fetal abnormalities as well as abortion had been reported by several studies in different part of the world. Due to lack of published data about CMV epidemiology in Ilam, the aim of current study was to determine the seroprevalence of specific viral IgM and IgG in spontaneous abortion cases as well as the age and socioeconomic status in the studied population in Ilam. Sera sample from 42 patients in abortion process as well as 30 healthy pregnant and 30 healthy women as negative control were collected and quantitative serological test to assess IgM/IgG against HCMV was performed using a commercial ELISA assay. SPSS software was used to analysis the results and demographic information. Among 42 patients in abortion process, IgG was found in 6 (14.28%) patients and IgM in 12(28.58%) cases. Based on demographical information, it was showed that IgG seropositivity correlate with the increase of age, but there is no correlation between IgM and age of patients. The results showed that there is a high seroPrevalence of HCMV IgM than IgG among pregnant women in the process of abortion in Ilam; correlation between Age and IgG anti body seroPrevalence was same as other reported. Based on the current studies, it seems that more sensitive and specific method such as NAT method is needed for determination of CMV and abortion procces.