Evaluation of effect of remifentanil and sufentanil on recovery profiles of patients in recovery 

Sufentanil and remifentanil are characterized by two different pharmacokinetic profiles. The aim of the present study was to evaluate the effects of sufentanil and remifentanil on recovery profiles of patients in recovery.  In a randomized clinical trial, 84 adult (17-41 years old) female patients who were considered for elective laparoscopic cholecystectomy surgery in Hazrat Rasool hospital were divided into two groups of Sufentanil (n=43) and Remifentanil (n=41) and their hemodynamic state, post operative nausea and vomiting (PONV) and need to its treatment, the post operative pain intensity and need to treatment of it were assessed. There were no significant differences regarding age and ASA Class. The operation duration was significantly longer in sufentanil group compared with remifentanil group (88.81±78.653 vs. 49.36±6.313 minutes, respectively). After surgery, heart rate showed a significant increase (in sufentanil group, 79.30±9.392 vs. 85.02±8.096 and in remifentanil group 79.17±7.629 vs. 83.98±8.774 beat/min). The post operative pain intensity and need to treatment of it were comparable among groups. Postoperative nausea was significantly higher in sufentanil group compared with remifentanil group (55.81% vs. 40.48%). However, there were no significant differences in post operative vomiting rate or need to treat it among study groups. Using remifentanil in patients undergoing laparoscopic cholecystectomy surgery is accompanied with minor differences with utilizing sufentanil.