The effect of essential oils and hydroalcoholic extract of caraway seed on oxidative stress parameters in rats suffering from acute lung inflammation before and after γ-irradiation

Acute lung inflammation is one of the chronic consequences of sepsis which leads to septic patients death. In consider to the side effects of using anti-inflammatory drugs, herbal drugs such as caraway seed has a great potential application with the aim of treating or/and decreasing the consequences of sepsis. In this study, CLP rat model was used to consider the protective role of hydroalcoholic extract and essential oils derived from caraway seeds in preventing tissue lung injury. In this regards, the effects of caraway extracts on lung oxidative stress parameters i.e. myeloperoxidase, lipid peroxidation and glutathione in different groups of rats were considered. Furthermore, in order to consider the effects of γ-irradiation on pharmacological properties of caraway extracts, four groups of rats treated with irradiated caraway seed extracts and the lung tissues were analyzed using oxidative stress parameters. The results of this study showed that caraway essential oils could modulate the oxidative stress parameters in this experimental acute inflammation; whereas, hydroalcoholic extract did not have any effects on these factors. γ-irradiation of caraway seeds at 10 and 25 kGy also had no effect on these properties of caraway extracts, so that essential oils but not hydroalcoholic extract derived from irradiated caraway seeds could amend oxidative parameters. The results of this study indicated that caraway essential oils could affect the consequences of acute lung injury and also preservation of caraway seeds by irradiation doesnt change its effects.