IgA Deficiency in Blood Donors in Zahedan, Iran

Anaphylactic reaction is one of the most important transfusion anaphylactic reactions in medicine. During transfusion if Individuals with IgA deficiency take blood which containing IgA, they would suffer from severe allergic reaction. Since there is a little known about this in different ethnic groups in Iran we have decided to evaluate this issue in Sistan & Baluchestan province in Iran. During one year, blood samples were collected from 3837 volunteer blood donors. Then the serum samples were tested for IgA titer by nephlometry and SRID techniques. According to our results only, one donor (0.026%) was found to have IgA less than 5mg/dl and 34(0.9%) cases had IgA: 5-30 mg/dl while 3798(99%) had IgA more than 30mg/dl. With regards to very low prevalence of IgA deficiency in blood donors in Southeast part of Iran, it seems that anaphylactic reactions most likely be due to other factors in the individuals that receive blood products.