Evaluation of IFN-y Serum Level in Type 2 Diabetic Patients with Nephopathy

Background and Cytokines are among the many immune system factors involved in diabetes pathogenesis. The level of cytokines expression such as IFN-y is varying in individuals and societies. Due to the fact that diabetes nephropathies are known as inflammatory disorders and the role of cytokines especially IFN-g in the establishment of inflammations is well understood, the present study was aimed to examine serum level of IFN-y in type 2 diabetes patients with nephropathy complications. In this cross sectional descriptive study, serum samples were obtained from 100 type 2 diabetes patients with nephropathy and 100 healthy controls for the analysis of IFN-g serum level (eBiosense, ESP). Consent forms were also filled out by patients and healthy controls according to the rules and regulations of Zahedan Islamic Azad University Ethical Committee. The obtained data and questionnaires were analyzed in SPSS using ANOVA; p<0.05 was considered as significant. The mean serum level of IFN-y was 16.09 y 7.74 pg/ml and 4.03 y 2.00 pg/ml in nephropathic patients and healthy controls, respectively. Statistical analysis of the data showed that the difference in the IFN-g level was not significant in nephropathic patients and controls. Based on the non-significant differences between the two groups, it seems that there is no association between the level of serum IFN-g and nephropathy in type 2 diabetics.