The effect of hydroalcoholic extracts of Zizipus vulgaris L. on burn healing

Traditionally, burn wound healing activities have been claimed for Zizipus vulgaris L, but there is not any evidence in literature for this effect of the plant. Therefore, this work was carried out to investigate the effect of hydroalcoholic extract of Zizipus vulgaris L. on burn healing. In an experimental study burn wounds were made by placing a hot plate with a surface area of 1.5 cm2 for 10s on the back of animals. 40 mice were designated in 4 groups. Animal were treated with vehicle or test substance two times per day for 21 days. The first group received nothing, second group Vaseline. Third and fourth group 1% and 10% Jujuba ointment two times/day, respectively. Percent of burn wounds healing and total time required for complete healing were evaluated. Results showed that 1% dose of Jujuba extracts had significant burn wound healing compared to control group (P<0.01). Zizipus vulgaris L. has considerable healing effect on burn wounds and its usage might be beneficial in these patients.