Seroprevalence of Toxoplasmosis in women with recurrent spontaneous abortion in ‎comparison with normal delivery

Toxoplasmosis, a parasitic infection, varies in its prevalence ‎in various countries. Some studies have suggested its role in the abortion. ‎The aim of this study was to determine the role of anti-Toxoplasma ‎antibody as an etiologic factor in recurrent pregnancy failure.‎ A case-control study was carried out on 120 ‎women who unexplained recurrent pregnancy loss (group I) with 50 ‎women had matched with normal reproductive outcome allocated as ‎control group. Sera from 120 cases and 50 controls were tested for anti-‎Toxoplasma IgG antibody by ELISA. The present study revealed a higher percentage of anti-‎Toxoplasma IgG antibodies positivity in women with repeated abortions ‎‎(17.5%) than control group (14%), although the difference between them ‎was not statistically significant (p=0.7).‎ The analysis of these results shows that in spite of proved ‎role of Toxoplasma gondii in fetal abortion, it is still controversial; ‎whatever toxoplasmosis can cause repeated abortion. Thus a study to ‎associate toxoplasmosis with recurrent abortions is difficult because a large ‎cohort of women with toxoplasmosis would be needed to assess the ‎incidence of otherwise unexplained recurrent abortions in them compared ‎with controls.‎