Comparison of two diagnostic methods of cystatin- c and serum creatinine level for the diagnosis of acute kidney injury after sever trauma within the firsth 24 hours in adult intensive care units

Acute kidney injury (AKI) is a common clinical problem in critically ill patients such as post traumatic situations. One of the main causes of poor outcome in these patients is lack of valuable serum markers for early diagnosis of AKI. In this study we compared cystatin-C and creatinine for estimation of GFR as a markers of AKI. we prospectively evaluated 300 patients admitted in adult intensive care units of a referral university affiliated hospital. Serum cystatin -C and serum creatinine were used to assess renal function according to RIFLE criteria to diagnose AKI. The crude Incidence of AKI according to RIFLE criteria based on GFR calculated with Creatinine was 14.7% and based on GFR with cystatin-C was 7%. Creatinine level was increased better than cystatin-C in the first 24 hours. AKI can be diagnosed by Creatinine level better than cystatin-C in the first 24 hours, so it is a better markers for evaluation of AKI.