The effect of Preoperative Naproxen on Pain Relief after Diagnostic Gynecologic Laparoscopy

Pain after outpatient diagnostic gynecologic laparoscopy, has different causes, so postoperative analgesia is important especially in order to patients early discharge. This study aimed to evaluate the efficacy and side effects of preoperative single dose rectal Naproxen in reducing postoperative pain and analgesic requirement in patients undergoing diagnostic gynecologic laparoscopy under general anesthesia. In this randomized clinical trial, forty healthy women undergoing diagnostic laparoscopy with general anesthesia were randomly allocated into two groups of 20 persons. About 60 minutes before operation, 500 mg Naproxen was administered rectally in study group (Naproxen Group) and the control group received placebo. Postoperative pain was evaluated immediately after arrival to recovery room and 1, 3, 6 hours postoperatively using visual analogue scale. Time to first analgesia administration, number of patients requiring additive analgesia and the other postoperative side effects were also controlled and recorded. Data were analyzed by nondependent T, χ2 and Fisher tests using SPSS software (version 15). Visual analogue scale scores were significantly lower in Naproxen group immediately and 3 hours after operation, (p<0.05) but not at 6 hours later (p>0.05) compared to placebo. The time to first analgesic requirement was longer in Naproxen group than placebo group (p<0.05). Postoperative analgesic requirement were lower in patients of Naproxen group than placebo group. Other side effects were not seen in both groups. Based on the above results we can conclude that prophylactic administration of rectal Naproxen could be effective on postoperative analgesia after diagnostic gynecologic laparoscopy and can lower analgesic requirement in postoperative period.