The Effect of Vitamin C Vaginal Tablets on Amsel Criterion in Patients with Bacterial Vaginosis

Bacterial vaginosis is the common cause of vaginitis among women of reproductive ages. Amsel criterion is the most accurate and applicable diagnosis method for bacterial vaginosis. The aim of the present study was to evaluate the effect of vitamin C vaginal tablets on the Amsel criterion. After confirmed diagnosis of bacterial vaginosis to Amsel criteria (having at least 3 out of the 4 characteristic symptoms including discharge, fishy odor, vaginal pH≥4.5, and presence of >20% of clue cell), 60 non pregnant women of 15-45 years of reproductive ages were enrolled in the present randomized clinical trail. The women were randomly assigned into two group (30 person in each group) to receive either 250 mg vaginal tablet of vitamin C, once a day, for 6 days or 75% metronidazole vaginal gel (5 gr once a day for 5 days. Results obtained from both groups were compared for demographics features, history and baseline clinical pictures. Participants were evaluated in follow-up visits (after treatment). After one week of applying of vitamin C vaginal tablets, 66.7% of cases had normal form of vaginal discharge,7 0% had negative whiff test, 40% had vaginal pH<4.5 and in 86.7% clue cell was less than 20% (p=0.0001). This study showed that vitamin C vaginal tablet has a significant effect on four of Amsel criteria especially on clue cell which is important for diagnosis of bacterial vaginosis.