The Effect of Cinnamon Extract on Serum Proteins Levels of Male Balb/c Mice

Cinnamon is a plant with many pharmaceutical effects. The present research evaluated the effects of Cinnamon bark extract on serum proteins level in male Balb/c mice. In this experimental study, 40 small Balb/c mice were chosen and divided into 5 groups: a control group, a case group, and three treatment groups. Normal saline was administered as placebo to the case group while the control group received no injections.. Cinnamon extract in doses of 50, 100 and 200 mg/Kg/48hr were injected intraperitoneally for 20 days to treatment groups. The levels of pre albumin, albumin, alpha-1, alpha-2, beta and gamma globulins were separated electrophoretically and calculated from the pattern of electrophoretogram. The result indicated that the levels of pre albumin decreased significantly in two experimental groups (doses of 50 and 100 mg/kg), the levels of alpha-1 and beta in 200 group, alpha-2 level in 100 and gamma in 100 and 200 groups increased significantly. The injection of 100 mg/Kg/48h extract of Cinnamon decreased (p<0.05) the albumin level in plasma in treatment group as compared to the control group. Results of this study indicated that the serum level of globulins has not changed dramatically by the extract of Cinnamon. Since albumin synthesis occurs in the liver cells‚ thus administration of Cinnamon may affect the function of liver cells.